Can you have one Excel spreadsheet that uploads two or more data types?

Is there a way to have one spreadsheet where the user enters two kinds of data, and then upload them both?

Uses include:

     New vendor and their first PO

     New employee and his benefit enrollments

     Project transactions and GL entry that offsets one side of the generated accounting

     Project labor transaction and additional GL entries to break out deductions, withholds, etc

     GL budget and actuals, especially in a mid-year conversion

     Provincial, federal, local tax rates all together

     Project budget and forecast