Best Practices for using a Screen Reader in 9.2 Campus Solutions self service

I would like some best practices advice on users needing to use a screen reader with campus solutions self service -- tile for manage classes -- so for enrollment.

Several of our users have found it clunky and difficult to use because you have to go through the entire left hand menu before you get to the main area where you actually search for classes.   Also once you get into the activity guide for enrollment, the options in the top menu bar versus on the page are very confusing.    I think if we adjust some of the navigation personalizations while in screen reader mode it might make it easier for them.   Does anyone have any suggestions about where to start and the best way to set things up for