What should be consideration for creation of Work Order and Work Center in a Plant?

Summary:

Dear Experts,

What all points we should consider before identifying and creating Work Area and Work Center in a Process Manufacturing Plant?

1) What should be the basic thumb rule for considering multiple Work Area and Work Centers in a plant?

2) What are benefits and complications of keeping multiple Work Area and Work Centers.

3) In which condition we should create multiple Work Area or Multiple Work Centers?

For Example: If there are three production trains to produce the same Finished Good, then shall we create One Work Area and three Work Centers, each work center with one resource or one Work Area and one work center with three resources? Will planning engine recommend differently in both cases for auto creation of work order?