Possible to Automatically Update DFF Value Linked to SQL Value Set?

Summary:

Is it possible to automatically update a DFF value on the invoice header that is set to a SQL Value Set?

Content (please ensure you mask any confidential information):

We have 2 DFF's on the invoice header which track a hold review process. This is used later for invoice workflows to determine if an invoice had the appropriate hold reviews completed which drives the final approval process. DFF #1 is a "yes/no" value. If an invoice went through Hold #1 I would like it to update to "yes". Then the invoice will enter a second hold process. Once the invoice completes hold #2 I would like the DFF #2 to be updated to "yes". Is this possible?