Enabling 'Bill in Advance of Receipt'

We have a small set of suppliers who require pre-payment on purchase orders. 

I want to flip this switch on, because I think it'll save us a lot of effort in creating bills for these suppliers, and in the receiving process.

Before I do so, I wanted to query the veterans out there:  are there any gotchas associated with doing so after some years of _not_ doing it this way?  Any side-effects?

I've searched the forums & NetSuite help & can only see that this would be a Very Good Thing, but nothing about what might happen after I flip the switch.