Alerts on Sales Order Line Changes

Is there any way to trigger a custom saved search to send an email alert when a sales order line changes? As far as I can tell, it is only possible to trigger alerts on changes to the main or body section of the sales order, but I would really love to be proven wrong.

The use case is wanting to automatically notify sales and manufacturing when a sales order line changes, like price, quantity, item#, text comments, custom column fields, etc. Yes, sometimes this will change the overall sales order (such as total amount), but sometimes it won't (such as text comments, custom column fields, item# substitution). And even if it does change the overall order, I can't figure out how to get the alert to show the sales order line that triggered the change.