Anyone experiencing intermittent, odd behavior when working with entering sales orders, etc..?

We were just upgraded to 2008.1 on friday night, and the girls who input our orders here are suddenly complaining that about half the time, it's just acting weird - i.e.
[LIST]
[*]line items won't load the base price
[*]the base / custom dropdown has 5 to 10 "custom" choices after the "base" choice (where there should be only one)
[*]if they click on a line-item to try and edit it, it copies that line-item to the bottom of the list instead of editing that one.... etc... etc....
[/LIST]

They are having to shut down their browser, and log back in and start over.  At which point, it usually starts behaving correctly again... for a while... then starts doing it again.