Matrix Items best practice

We sell a lot of apparel with multiple colors and sizes. We have compacted our matrix item lists down to about 12, about 4 color lists and 6 size lists, e.g. one color list A contains 60 colors. So we have hundreds of products that utilize this color list A, but each product may only utilize 3, 4, 5 or 6 of the list of 60 (each product might have two colors in common e.g. black and coyote but the other colors maybe unique to each product).

My question is:
Is this a best practice to have pretty much all our colors in one matrix item list when it comes to integrating with a non NetSuite website (we use Big Commerce). Or is it better to have a lot of separate NetSuite matrix item lists (e.g. with 3, 4, 5 or 6 colors in each list) and match each list to its respective product(s). Or should either way work without issues. Integrating matrix items with our Big Commerce platform seems to be a major issue for our third party integrator at present..