MySQL replication between instance and MDS

Summary:

Is it possible to replicate from mysql running on an compute instance and a DB System (MDS)

Content (required):

I have mysql running on a OL8 compute instance. I would like to set up inbound replication between that and a MySQL DB System. The compute instance and the MDS are both in the same compartment, same vcn, same subnet. However after I set up the channel, I see the following when I run show slave status on the MDS:

Last_IO_Error: error connecting to master 'repluser001@10.0.1.243:3306' - retry-time: 60 retries: 1 message: Can't connect to MySQL server on '10.0.1.243:3306'